# GLP-1 Storage: How Long Out of the Fridge?

> How long Ozempic, Wegovy, Mounjaro, Zepbound, Trulicity and more can stay out of the fridge — the in-use limit from each FDA label.

Source: https://glp-1-app.com/learn/glp-1-storage/

Education · not medical advice

## GLP-1 storage: how long can it be out of the fridge?

The number is on your carton, and it is not the same for every product — even for two products containing the same drug.

There is no single answer for “semaglutide” or “tirzepatide.” The in-use limit is set per **presentation**, not per molecule: an Ozempic multi-dose pen allows **56 days** out of the fridge, while Wegovy — the same drug — allows **28**. Check the carton you are actually holding.

Products below that contain the same active ingredient are listed separately on purpose, because their labels give different answers.

### In-use limits from the FDA labels

Quoted from each product's approved label. “In use” means after first use, or after it leaves the refrigerator — whichever the label defines.

| Product | Before first use | Once in use | Source |
| --- | --- | --- | --- |
| Ozempicsemaglutide · multi-dose pen | 2–8 °C | 56 days(15–30 °C) | [Ozempic FDA label (DailyMed), §16](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=adec4fd2-6858-4c99-91d4-531f5f2a2d79) |
| Ozempicsemaglutide · single-dose prefilled syringe | 2–8 °C | 28 days(8–30 °C) | [Ozempic FDA label (DailyMed), §16](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=adec4fd2-6858-4c99-91d4-531f5f2a2d79) |
| Wegovysemaglutide · single-dose pen | 2–8 °C | 28 days(8–30 °C)Applies before the pen cap is removed. | [Wegovy FDA label (DailyMed), Instructions for Use](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f5e548d0-cc79-4c34-a3f5-e20a5b8b6564) |
| Mounjarotirzepatide · single-dose pen or vial | 2–8 °C | 21 days(≤30 °C) | [Mounjaro FDA label (DailyMed), §16.2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0) |
| Mounjarotirzepatide · opened multi-dose vial or KwikPen | 2–8 °C | 30 days(≤30 °C)Or 30 days after first use, or after 4 weekly doses — whichever comes first. | [Mounjaro FDA label (DailyMed), §16.2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0) |
| Zepboundtirzepatide · single-dose pen or vial | 2–8 °C | 21 days(≤30 °C) | [Zepbound FDA label (DailyMed), §16.2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=487cd7e7-434c-4925-99fa-aa80b1cc776b) |
| Zepboundtirzepatide · opened multi-dose vial or KwikPen | 2–8 °C | 30 days(≤30 °C)Or 30 days after first use, or after 4 weekly doses — whichever comes first. | [Zepbound FDA label (DailyMed), §16.2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=487cd7e7-434c-4925-99fa-aa80b1cc776b) |
| Trulicitydulaglutide · single-dose pen | 2–8 °C | 14 days(≤30 °C) | [Trulicity FDA label (DailyMed), §16.2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=463050bd-2b1c-40f5-b3c3-0a04bb433309) |
| Victozaliraglutide · multi-dose pen | 2–8 °C | 30 days(15–30 °C) | [Victoza FDA label (DailyMed), §16](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5a9ef4ea-c76a-4d34-a604-27c5b505f5a4) |
| Saxendaliraglutide · multi-dose pen | 2–8 °C | 30 days(15–30 °C) | [Saxenda FDA label (DailyMed), §16](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3946d389-0926-4f77-a708-0acb8153b143) |
| Rybelsussemaglutide · tablets | 20–25 °C | No day limit — use until the expiry dateKeep in the original bottle to protect from moisture. | [Rybelsus FDA label (DailyMed), §16](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=27f15fac-7d98-4114-a2ec-92494a91da98) |
| Foundayoorforglipron · tablets | 20–25 °C | No day limit — use until the expiry dateLight sensitive — keep in the original bottle and carton. | [Foundayo (orforglipron) FDA label (DailyMed), §16.2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8ac446c5-feba-474f-a103-23facb9b5c62) |

These are the manufacturers' own figures, not our recommendation. Labels are revised, packaging differs by country, and your carton is the authority. If a product has been warmer than its limit, frozen, or out longer than the label allows, ask a pharmacist rather than guessing.

### Why the same drug has two different answers

A reusable multi-dose pen is designed to be carried and used repeatedly, so it is tested and approved for a longer in-use window. A single-dose pen or syringe is not. That is why Ozempic's pen gets **56 days** and Wegovy's single-dose pen gets **28** — same molecule, different device, different approved limit. Tablets work differently again: Rybelsus and Foundayo have no in-use clock at all and simply run to their expiry date.

### What the labels agree on

Across every injectable here, three rules are consistent:

- **Refrigerate before first use**, at 2–8 °C — not in the freezer, and not against the cooling element.
- **Never use it if it has been frozen**, even if it has thawed and looks normal.
- **Keep it in the original carton** and protect it from heat and light; 30 °C is the ceiling for every injectable listed.

### Common questions

#### How long can Ozempic be out of the fridge?

The Ozempic multi-dose pen may be stored for 56 days at 15–30 °C after first use, per its FDA label. The single-dose prefilled syringe is different: up to 28 days at 8–30 °C. Check which presentation you have, and confirm against your carton.

#### How long can Wegovy be out of the fridge?

Up to 28 days at 8–30 °C in its original carton, before the pen cap is removed, per the FDA-approved Instructions for Use. Wegovy's label says to throw the pen away if it has been frozen, exposed to light, above 30 °C, or out of the refrigerator for 28 days or more.

#### Is Mounjaro the same as Zepbound for storage?

Yes — both are tirzepatide from the same manufacturer and their storage sections are word for word identical. A single-dose pen or vial allows up to 21 days unrefrigerated at or below 30 °C; an opened multi-dose vial or KwikPen is discarded after 30 days at room temperature, 30 days after first use, or 4 weekly doses, whichever comes first.

#### What happens if it got too warm or was frozen?

Every label here says not to use a product that has been frozen, and several say to discard it if it has been above 30 °C. This page cannot tell you whether a specific pen is still usable — that is a question for the pharmacy that dispensed it, and they can usually answer it in a phone call.

#### Do the tablets need refrigerating?

No. Rybelsus and Foundayo are stored at 20–25 °C with excursions permitted to 15–30 °C, and they have no in-use day limit — they run to the printed expiry date. Rybelsus should stay in its original bottle to protect from moisture; Foundayo is light sensitive and should stay in its bottle and carton.

### Keep reading

- [GLP-1 half-life](https://glp-1-app.com/learn/glp-1-half-life/)
- [How reconstitution works](https://glp-1-app.com/learn/how-reconstitution-works/)
- [Units vs mg](https://glp-1-app.com/learn/units-vs-mg/)

Educational only — not medical advice. These figures are quoted from FDA-approved labels current at the time of writing and may be revised; packaging and approved storage can differ by country. Your product's carton and your pharmacist are the authority on your medication.

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